High-dose methotrexate as secondary chemotherapy in metastatic soft-tissue sarcomas
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چکیده
منابع مشابه
High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Children with High-Risk or Recurrent Bone and Soft Tissue Sarcomas
Despite increasing evidence that high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) might improve the survival of patients with high-risk or recurrent solid tumors, therapy effectiveness for bone and soft tissue sarcoma treatment remains unclear. This study retrospectively investigated the feasibility and effectiveness of HDCT/auto-SCT for high-risk or recurrent bon...
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to define efficacy of pre-operative chemotherapy in down staging of advanced non-round cell soft tissue sarcomas. from sep 2002 to dec 2005, 70 patients were treated by ifosfamid, mesna, cisplatin, adriamycin, mitomycin and subsequent surgery. postoperatively, patients received radiotherapy in cases of microscopically incomplete resection or local recurrence. the median age of the patients was ...
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Together with surgery and radiotherapy, systemic treatment with cytotoxic chemotherapy and molecular targeted agents is one of the main therapeutic pillars in the treatment of soft-tissue sarcomas and is the mainstay of treatment in patients with advanced or metastatic disease. Unlike other more common malignancies such as breast and colorectal cancer, the role of chemotherapy when used in the ...
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Purpose. To assess the effectiveness of Ir-192 interstitial brachytherapy as an adjunct to wide local excision as a functionsaving strategy for soft tissue sarcomas.Subjects and methods. From September 1993 to April 1998, 20 consecutive patients diagnosed with soft tissue sarcomas were treated with a combination of wide local excision and interstitial brachytherapy. In 16 patients brachytherapy...
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BACKGROUND Ifosfamide has important activity in pretreated soft tissue sarcomas (STS), and recent data support a clinically significant dose-response relationship for this agent. Administration by continuous infusion and hematopoietic support have rendered dose intensification regimens possible by reducing both hematologic and non-hematologic toxicities. The optimal dose and schedule of ifosfam...
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ژورنال
عنوان ژورنال: Cancer
سال: 1980
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19800915)46:6<1345::aid-cncr2820460608>3.0.co;2-r